Sugar, Fat Oxidation, Protective Saturated Fat, Sir Philip Randle and Bernardo Houssay


  1. “I won the Nobel Prize in Medicine in 1947 for my work on diabetes showing polyunsaturated fatty acids causative and coconut oil, protein, and sucrose protective. My conclusions were supported by Sir Philip Randle and his Randle Effect/Cycle years later. – Bernardo Houssay” Rob Turner
  2. “The antagonism between fat and sugar that Randle described can involve the suppression of sugar oxidation when the concentration of fats in the bloodstream is increased by eating fatty food, or by releasing fats from the tissues by lipolysis, but it can also involve the suppression of fat oxidation by inhibiting the release of fatty acids from the tissues, when a sufficient amount of sugar is eaten.” Raymond Peat, PhD
  3. “The inhibition of fat oxidation, and supporting sugar oxidation, now seems to be appropriate for preventing or treating any age-related degenerative disease.” Raymond Peat, PhD
  4. “High free fatty acids in the blood impair glucose oxidation. Muscle glycogen synthesis is also negatively affected. High free fatty acids are found in the diabetics, the insulin resistant, the obese, and AIDS patients. Anything that promotes the release of fatty acids into the blood is a factor to consider in diabetes progression or correction (i.e. estrogen, stress, growth hormone, exercise, adrenaline, cortisol, serotonin, lactic acid, low thyroid, malnutrition, darkness).” Rob Turner, The Randle Cycle (Glucose-Fatty Acid Cycle)
  5. PUFA Causative in Diabetes – Randle Cycle
    Vladimir Heiskanen: Oh, okay! I am not completely sure about this, but I think that in some of Houssay’s studies, corn oil was associated with better ourcome than butter – so the results weren’t always linear.
    Rob Turner: Yes not linear in his study, but coconut oil offered complete protection from diabetes.
  6. Data since suggests that PUFA offer a negative effect on glucose metabolism relative to saturated fat.
  7. Science. 1947 May 23;105(2734):548-9.
    Experimental Diabetes and Diet.
    Houssay BA, Martínez C.
    “In rats fed other high fat diets (olive oil, butter) the actions of alloxan were not modified, but there was a slight diminution when high oleomargarine or corn oil diets were fed. However, complete protection was observed when a high coconut oil diet was administered.”
  8. Diabetes. 2002 Jun;51(6):1825-33.
    The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats.
    Dobbins RL1, Szczepaniak LS, Myhill J, Tamura Y, Uchino H, Giacca A, McGarry JD.
    “These data indicate that prolonged exposure to saturated fat enhances glucose-stimulated insulin secretion (but this does not entirely compensate for insulin resistance), whereas unsaturated fat, given in the diet or by infusion, impairs GSIS. Inferences regarding the impact of fatty acids on GSIS that are based on models using unsaturated fat may not reflect the effects of saturated fat.”
  9. Diabetes. 1989 Oct;38(10):1314-9.
    Effects of fish oil supplementation on glucose and lipid metabolism in NIDDM.
    Borkman M1, Chisholm DJ, Furler SM, Storlien LH, Kraegen EW, Simons LA, Chesterman CN.
    “In summary, dietary fish oil supplementation adversely affected glycemic control in NIDDM subjects without producing significant beneficial effects on plasma lipids. The effect of safflower oil supplementation was not significantly different from fish oil, suggesting that the negative effects on glucose metabolism may be related to the extra energy or fat intake.”

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